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Collectively, our findings establish the microbiotabutyratemTORC1ISR relay as a core driver of PBAT-MPs-induced neurotoxicity and highlight restoration of butyrate signaling as a promising microbiota-based strategy for preventing microplastic-induced brain lipotoxic injury

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Depletion of SAMe and methionine can lead to changes in DNA methylation patterns, potentially leading to the formation of cancer cells